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observed a modest increase in IGF-1 mRNA levels by the end of the first week in a rabbit flexor tendon repair model, which surged nearly six-fold by week three and remained elevated at week 6 ( In the single-time-point study, Tsubone et al

doi: 10.1111/j.1572-0241.2008.02024.x 247 MartinetWLoofHDDe MeyerGRY

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Discussion Michael addition reaction has been widely applied in organic synthesis and bioconjugation to build carboncarbon and carbonheteroatom bonds based on its forward reaction

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